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Year Number of Results
1862 1
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1918 1
1929 1
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1947 2
1949 1
1955 1
1957 3
1958 2
1960 1
1961 2
1963 4
1964 2
1965 9
1966 6
1967 9
1968 16
1969 24
1970 16
1971 21
1972 11
1973 25
1974 30
1975 70
1976 68
1977 83
1978 79
1979 111
1980 118
1981 152
1982 166
1983 262
1984 292
1985 314
1986 410
1987 494
1988 605
1989 746
1990 992
1991 1297
1992 1513
1993 1629
1994 1972
1995 1958
1996 1732
1997 1177
1998 1379
1999 1376
2000 1405
2001 1362
2002 1324
2003 1338
2004 1393
2005 1312
2006 1336
2007 1284
2008 1251
2009 1231
2010 1314
2011 1298
2012 1309
2013 1154
2014 1051
2015 1042
2016 916
2017 856
2018 848
2019 855
2020 850
2021 885
2022 793
2023 845
2024 321

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Intrinsic base substitution patterns in diverse species reveal links to cancer and metabolism.
Gelova SP, Doherty KN, Alasmar S, Chan K. Gelova SP, et al. Genetics. 2022 Nov 1;222(3):iyac144. doi: 10.1093/genetics/iyac144. Genetics. 2022. PMID: 36149294 Free PMC article.
Analyses of large-scale cancer sequencing data have revealed that mutagenic processes can create distinctive patterns of base substitutions, called mutational signatures. Interestingly, mutational patterns resembling some of these signatures can also be observed in …
Analyses of large-scale cancer sequencing data have revealed that mutagenic processes can create distinctive patterns of base subs …
Transition Substitution of Desired Bases in Human Pluripotent Stem Cells with Base Editors: A Step-by-Step Guide.
Park JC, Kim KT, Jang HK, Cha HJ. Park JC, et al. Int J Stem Cells. 2023 May 30;16(2):234-243. doi: 10.15283/ijsc22171. Epub 2023 Feb 28. Int J Stem Cells. 2023. PMID: 36823978 Free PMC article.
On the contrary, due to the lack of Cas9 endonuclease activity, base editors (BEs) such as adenine base editor (ABE) and cytosine base editor (CBE) allow precise base substitution by conjugated deaminase activity, free from DSB formation. Despit …
On the contrary, due to the lack of Cas9 endonuclease activity, base editors (BEs) such as adenine base editor (ABE) and cytos …
The Effect of Base and Nucleophile on the Nucleophilic Substitution of Methoxytropone Derivatives: An Easy Access to 4- and 5-Substituted Multifunctional Azulenes.
Kumar NR, Agrawal AR, Choudhury A, Zade SS. Kumar NR, et al. J Org Chem. 2020 Jul 17;85(14):9029-9041. doi: 10.1021/acs.joc.0c00951. Epub 2020 Jun 17. J Org Chem. 2020. PMID: 32486646
The nucleophilic substitution on 3-substituted 2-methoxytropones to form azulenes is dependent on the nucleophile and base employed. With bulkier nucleophiles (ethyl/methyl cyanoacetate), the reaction proceeds with the abnormal nucleophilic substitution …
The nucleophilic substitution on 3-substituted 2-methoxytropones to form azulenes is dependent on the nucleophile and base …
Base substitution mutations in uridinediphosphate-dependent glycosyltransferase 76G1 gene of Stevia rebaudiana causes the low levels of rebaudioside A: mutations in UGT76G1, a key gene of steviol glycosides synthesis.
Yang YH, Huang SZ, Han YL, Yuan HY, Gu CS, Zhao YH. Yang YH, et al. Plant Physiol Biochem. 2014 Jul;80:220-5. doi: 10.1016/j.plaphy.2014.04.005. Epub 2014 Apr 23. Plant Physiol Biochem. 2014. PMID: 24811677
Steviol glycosides, extracted from the leaves of Stevia rebaudiana (Bert) Bertoni, are calorie-free sugar substitute of natural origin with intensely sweet (Boileau et al., 2012). ...So the nonsense mutation and amino acid substitution mutation resulted in the low l …
Steviol glycosides, extracted from the leaves of Stevia rebaudiana (Bert) Bertoni, are calorie-free sugar substitute of natural origi …
Target-AID-Mediated Multiplex Base Editing in Porcine Fibroblasts.
Yum SY, Jang G, Koo O. Yum SY, et al. Animals (Basel). 2021 Dec 16;11(12):3570. doi: 10.3390/ani11123570. Animals (Basel). 2021. PMID: 34944345 Free PMC article.
It can be used to substitute cytosine for thymine in 3-5 base editing windows 18 bases upstream of the protospacer-adjacent motif site. In the current study, we demonstrated Target-AID-mediated base editing in porcine cells for the first time. We targeted mul …
It can be used to substitute cytosine for thymine in 3-5 base editing windows 18 bases upstream of the protospacer-adjacent mo …
Unbiased Estimate of Synonymous and Nonsynonymous Substitution Rates with Nonstationary Base Composition.
Guéguen L, Duret L. Guéguen L, et al. Mol Biol Evol. 2018 Mar 1;35(3):734-742. doi: 10.1093/molbev/msx308. Mol Biol Evol. 2018. PMID: 29220511 Free PMC article.
The measurement of synonymous and nonsynonymous substitution rates (dS and dN) is useful for assessing selection operating on protein sequences or for investigating mutational processes affecting genomes. ...Standard methods for estimating dN, dS, or omega rely on the assu …
The measurement of synonymous and nonsynonymous substitution rates (dS and dN) is useful for assessing selection operating on protein …
Hyperinflation of Nitroprusside.
Cobb A, Thornton L. Cobb A, et al. J Pharm Pract. 2018 Aug;31(4):382-389. doi: 10.1177/0897190018762182. J Pharm Pract. 2018. PMID: 30071785
A therapeutic interchange, wherein a drug with similar efficacy is substituted for another, is often an appropriate strategy in this scenario. ...Some hospitals have reported significant cost savings without adverse outcomes by substituting clevidipine or nicardipin …
A therapeutic interchange, wherein a drug with similar efficacy is substituted for another, is often an appropriate strategy in this …
Effect of lupine as cheese base substitution on technological and nutritional properties of processed cheese analogue.
Awad RA, Salama WM, Farahat AM. Awad RA, et al. Acta Sci Pol Technol Aliment. 2014 Jan-Mar;13(1):55-64. doi: 10.17306/j.afs.2014.1.5. Acta Sci Pol Technol Aliment. 2014. PMID: 24583384
The peeled seeds were minced, blended to get very fine paste and kept frozen until used. RESULTS: Lupine paste was used to substitute 25, 50, 75 and 100% of cheese in base formula of processed cheese analogue (PCA). ...Body and texture score of PCA was the mostly af …
The peeled seeds were minced, blended to get very fine paste and kept frozen until used. RESULTS: Lupine paste was used to substitute …
Base substitution spectra of nalidixylate resistant mutations induced by monochromatic soft X and 60Co gamma-rays in Bacillus subtilis spores.
Takahashi N, Hieda K, Morohoshi F, Munakata N. Takahashi N, et al. J Radiat Res. 1999 Jun;40(2):115-24. doi: 10.1269/jrr.40.115. J Radiat Res. 1999. PMID: 10494143 Free article.
Among eighteen alleles of the gyrA mutations, eight were single-base substitutions, nine were tandem double-base substitutions, and one was a double substitution skipping a middle base pair. About 6% of the radiation-induced mutations wer …
Among eighteen alleles of the gyrA mutations, eight were single-base substitutions, nine were tandem double-base sub …
Correction of substitution, deletion, and insertion mutations by 5'-tailed duplexes.
Kawai H, Sato K, Kato T, Kamiya H. Kawai H, et al. J Biosci Bioeng. 2024 Mar;137(3):157-164. doi: 10.1016/j.jbiosc.2023.12.011. Epub 2024 Jan 11. J Biosci Bioeng. 2024. PMID: 38216338
Among the mutations, three-base consecutive substitutions were efficiently repaired. The correction efficiencies of deletion mutations were similar to those of substitution mutations, and two to three times higher than those of insertion mutations. Up to thre …
Among the mutations, three-base consecutive substitutions were efficiently repaired. The correction efficiencies of deletion m …
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